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Apr 25, 2022 · For pediatric patients with heart failure, dosages of digoxin should be started and based on the lower end of the recommended dose to avoid unnecessary toxicity
Go to: MECHANISM OF ACTION The combined
Cautious
Epidemiology Approximately 1% of patients with heart failure treated with digoxin develop toxicity
The trend toward a lower dose of digoxin stems from at least two factors: availability of radioimmu- noassay for measuring digoxin content, which made it 8 7 4
Article history Share Tools Serum digoxin levels in nontoxic patients obtained 6 to 24 hours after
It can also occur when levels of the drug build up for other
NewYork-Presbyterian Queens offers advanced-level care for high-risk infants born with extremely
It is also used to treat a heart rhythm problem called atrial fibrillation
First, pharmacokinetic studies indicate that somewhat higher doses are required in the infant to attain the same serum levels as in the adult
In congestive heart failure, Digoxin is usually the preferred drug in pediatric patients due to its rapid action and shorter half A persistently patent ductus arteriosus (PDA) can have clinical consequences depending on the degree of left-to-right shunting and ductal steal
The most common indication for digoxin toxicity was heart failure symptoms (61
Digoxin is extensively secreted via P-gp within the tubular cell
Cardiac glycosides, including digitalis and digoxin, have long-standing use in clinical practice
Cautious practice would include digoxin doses aimed at moderate serum levels (1
g
It is the only oral inotrope that does not increase long-term mortality in chronic heart failure and has few side effects when dosed appropriately on the basis of serum concentration
6 to 11
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0 nanograms/mL); always interpret results in the clinical context
Age
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Some have hypothesized that digoxin may exert its protective effect PEDIATRIC PATIENTS
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Digoxin is one of common medications used for pediatric heart failure [], especially for premature infants or neonates with clinically significant patent ductus arteriosus (PDA), which is a condition where the ductus arteriosus fails to close after birth
(J Pediatr
Digoxin is used to treat congestive heart failure, usually in combination with a diuretic (water pill) and an angiotensin-converting enzyme (ACE) inhibitor