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Methods We randomly assigned 10,101 postmenopausa Early Effects of Raloxifene on Clinical Vertebral Fractures at 12 Months in Postmenopausal Women With Osteoporosis | Orthopedics | JAMA Internal Medicine | JAMA Network
Subsequently, raloxifene underwent extensive clinical investigation, with the goal of understanding the
It can help to strengthen bones, making them less likely to break
Raloxifene decreases bone resorption and turnover and may be used for the treatment or prevention of osteoporosis
Raloxifene is not for use in men
The proportion of participants with undetectable SARS-CoV-2 after seven days of treatment with raloxifene 60 mg [36
Some side effects may occur that usually do not need medical attention
2273; What side effects may I notice from receiving this medication? Side effects that you should report to your care team as soon as possible: Allergic reactions—skin rash, itching, hives, swelling of Raloxifene should only be given to postmenopausal women but if you inadvertently become pregnant during treatment tell your doctor immediately
Coughing blood
By regulating transforming factor- 3 gene expression and suppressing interleukin-6 promoter activity, raloxifene maintains bone mass by inhibiting the dif-ferentiation and bone-resorptive activities of osteoclasts [7,9]
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This helps prevent bone breakdown and improve bone mineral density ( BMD ), which is a measure of how dense your bones are
The scratch as - say also revealed that raloxifene significantly reduced the migratory potential of HCT-116 cells in-vitro
Placebo subjects in MORE continued receiving placebo in the CORE trial
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In both cases, raloxifene was given for osteoporosis prevention in the absence of vasomotor symptoms
There was no significant difference in mean (±SD) depression scores at three years (placebo group, 1
swelling of hands, ankles, or feet
These appealing attributes make raloxifene a potential treatment for osteoporosis and other menopause related risks in middle aged and elderly women