Seven trials were included in this analysis, including the three studies from the lithium versus placebo analysis with an
Suicide risk in bipolar disorder during treatment with lithium and divalproex
1) Anti-Suicidal Properties
290
2016; Miura et al
Bowden CL, Brugger AM, Swann AC, et al
Google Scholar PubMed Methods
We sought to establish whether the administration of valproate (VPA), a commonly used anticonvulsant and mood stabilizer, known to inhibit HDAC and modulate the epigenome to promote neuroplasticity (Phiel et
Martinez-Aran A, Reinares M, Goikolea J M, Benabarre A, Torrent C, Comes M A, et al
Randomized, double-blind, parallel-group study of treatment outcomes in patients with manic-depressive illness
: Suicide risk in bipolar disorder during treatment with lithium and divalproex
One widely used agent is sodium As noted, depressive, dysthymic, and mixed states account for the majority of illness-burden in BD, and are strongly predicted by initial depressive, mixed, or anxious episodes (Goodwin and Jamison 2007; Yildiz et al
This paper is a systematic review of the available data concerning the treatment of bipolar disorder: a systematic Medline search concerning treatment guidelines and clinical trials
Two cases of agranulocytosis occurred several years after clozapine initiation (Frankenburg et al
Using lithium together with divalproex sodium may increase side effects such as dizziness, drowsiness, confusion, and difficulty concentrating
2017; Perugi et al
2003; Keck et al
This rate was nearly 9
, 2012, Gitlin et al
found lithium monotherapy to be superior to monotherapy with other maintenance mood stabilizers in Geddes JR, Burgess S, Hawton K, Jamison K, Goodwin GM
In the Geri-BD study, 224 adults age 60 or older with BD type I whose most recent episode was manic, hypomanic, or mixed were given either lithium (0
65% of reviewers reported a positive effect, while 21% reported a negative effect