Generic name: probenecid [ proe-BEN-a-sid ] Brand name: Benemid
Probenecid is used in the treatment of chronic gout or gouty arthritis
Probenecid, also sold under the brand name Probalan, is a medication that increases
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If you are worried about any side effects, you should contact your doctor as soon as possible
If gouty arthritis is not controlled or if 24-hour uric acid excretion is not >700 mg, increase daily dosage by 1 tablet every 4 weeks 600 mg benzylpenicillin contains 38
10 dosage units (6g) reflects the lowest number of dosage units for which the threshold of 17mmol (391mg) of sodium is reached
5 mg every other day on days 1 to 21, every 28 days
Common side effects of probenecid may include: headache, dizziness; nausea, vomiting, loss of appetite; flushing (sudden warmth, redness, or tingly feeling); sore gums; urinating more than usual; itching, rash; or
Print patient leaflet as text only They are also used to prevent flare-ups of gout when treatment is started with other drugs such as allopurinol, probenecid and sulfinpyrazone
In the first of 2 clinical trials, 7 (7%) of 96 patients receiving intravenous ceftriaxone 2 g and oral probenecid 1 g daily were reported to fail therapy compared with 8 (8%) of 98 patients receiving intravenous cefazolin 2 g and oral probenecid 1 g daily
Further increases of up to 2 g daily by increments of 500 mg every 4 wk may be given if needed
Children under 40kg
Phenoxymethylpenicillin may reduce the excretion of methotrexate causing an increased risk of toxicity
** The 10,000 IU/ml (10 ml vial) and 25,000 IU/ml (4 ml vial) multidose vials contain benzyl alcohol
Paediatric population: Pivmecillinam hydrochloride should not be used in children and adolescents below 18 years because the efficacy and safety have not yet been established
Probenecid causes reduced excretion of cefalexin leading to increased plasma concentrations
Mirtazapine should not be used in the treatment of children and adolescents under the age of 18 years
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