Primary endpoints were determination of dose-limiting toxicities at the maximum administered dose, safety and tolerability, and the proportion of patients with objective
By H
Reduce daily dose of Cefdinir in patients with transient or persistent renal impairment (CrCl < 30mL/min)
3 + 0
For further recommendations on alternative antibiotic regimens cefdinir 14 mg/kg/dose daily x 7 days (max dose: 600 mg/day) Early Antibiotic Treatment for Pediatric Febrile Urinary Tract Infection and Renal Scarring
Antibiotic resistance patterns of outpatient pediatric urinary tract infections
However, safety and efficacy have not been established in infants younger than 6 months of age
Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of cefdinir in children
23 In acute cystitis, single dose regimen has less efficiency and high recurrence rate (20%)
Guidelines recommend cefdinir as an alternative to amoxicillin or amoxicillin; clavulanate for infections due to H
As a result, many organisms resistant to penicillins and some cephalosporins are susceptible to cefdinir
(max 500 mg/dose) Clindamycin or Cefdinir 14mg/kg PO Daily (max 600 mg/day) or Ceftriaxone 50mg/kg IM or IV daily for 1-3 days (max 2000mg/dose) Reference: Pediatrics 2013: 131 (3): e964-e999
1Children who are not up-to-date for age with conjugate vaccines for S
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It belongs to the class of medicines known as cephalosporin antibiotics
5% of upper respiratory tract infections (URIs) are complicated by acute bacterial sinusitis (ABS)