7 mg/g) and therefore more in the dissolved state partitioned more in the external aqueous phase when compared to dexamethasone with a lower solubility in dichloromethane (0
Freely soluble in water (heating increases its solubility in water); soluble in dilute acids and alkalies and in basic organic solvents such as pyridine; insoluble in the common organic solvents
Among all the runs, the highest solubility of DEX was observed for run no
Dichloromethane (DCM, methylene chloride, or methylene bichloride) is an organochlorine compound with the formula C H 2 Cl 2
Experimental solubility of dexamethasone was obtained in binary aqueous mixtures of ethanol, methanol and acetonitrile at 298
5, and 5% w/w), dexamethasone solubility was increased (0
The effect of ethanol, as an organic phase co-solvent, on the characteristics of dexamethasone containing poly (lactide-co-glycolide) (PLGA) microspheres prepared
4
2: 2
Liver and muscle tissue are extracted with a mixture of aqueous buffer and acetonitrile
The solubility of
37 mg/mL
dichloromethane: slightly soluble methanol: freely soluble water: practically insoluble
The solubility of water (2) in dichloromethane (1) has been reported from 19 laboratories
Louis, MO
Concomitant administration of dexamethasone with inducers of CYP3A4, such as phenytoin, barbiturates (e
Freely soluble in water; slightly soluble in ethanol (~750 g/L) TS; practically insoluble in dichloromethane R
Additional information
Solubility of dexamethasone was determined in different oil (labrafac lipophil wl 1349, transcutol-P, olive oil, almond oil, labrafac lipophil PG), surfactants (Labrasol, Tween 80) and cosurfactant (Capryol 90, Isopropyl alcohol) by dissolving an excess amount of dexamethasone in 3 mL of oil, surfactant and cosurfactant using a stirrer at 37˚C Dexamethasone is an anti-inflammatory glucocorticoid and a synthetic corticosteroid used for treating corneal inflammation
3
Dexamethasone Acetate is a glucocorticoid with anti-inflammatory properties
It favors apoptosis in chondrocytes and impairs development of bone
5, and 5% w/w), dexamethasone solubility was increased (0
Methylene chloride was selected as a common solvent to dissolve PLGA 85:15 and disperse HIP complex
6 55
acetone: freely soluble dichloromethane: slightly soluble methanol: freely soluble water: practically insoluble
Corticosteroids occur naturally in the body, and help to maintain health and well-being
(b) When the maximum possible amount of solute has dissolved, the solution becomes saturated
Acetonitrile, tetrahydrofuran, dichloromethane, and diethyl ether were bought from Scharlau (Barcelona, Spain), and Maxidex ® (dexamethasone 0
- 8 of 8 defined stereocentres
For an immiscible compound, DCM is quite soluble in water (~20g will dissolve in a litre of water)
Each tablet contains 0