Promethazine is a an antagonist of histamine H1, post-synaptic mesolimbic dopamine, alpha adrenergic, muscarinic, and NMDA receptors
Promethazine also functions as a weak dopamine antagonist, blocking dopamine-2 receptors in the chemoreceptor trigger zone, thus decreasing nausea and vomiting
Dopamine
The three classes include: phenothiazines (prochlorperazine, chlorpromazine, and promethazine), butyrophenones (droperidol and haloperidol), and metoclopramide
Phenothiazines antagonize many receptors, incl dopamine receptors (primarily D 2), muscarinic receptors, serotonin receptors, α 1 adrenergic receptors and H 1 histamine receptors
Methysergide is a 5-HT 2A antagonist and nonselective 5-HT 1 receptor blocker
Structural differences from the neuroleptic phenothiazines result in its relative lack (1/10 that of chlorpromazine ) of dopamine antagonist properties
They are mainly used in research, having found limited clinical application in human medicine
This activity illustrates the indications, action, and contraindications for phenothiazine as a valuable agent in
They also tend to block serotonin receptors in addition to Promethazine: Drugs to treat hyperkinetic movements such as chorea and tardive dyskinesia: Tetrabenazine: Xenazine: Decrease dopamine stores: Deutetrabenazine: Austedo: Presumably if you took extreme doses of promethazine, to the point where it blocks enough dopamine and serotonin receptors to be considered an antipsychotic, it might generally decrease any sense of euphoria (and of course such a dose would also produce massive anticholinergic effects, which aren't exactly pleasant either), but at
A dopamine D2 receptor antagonist used in the treatment of acute and chronic schizophrenia, and in the prevention and treatment of postoperative nausea and vomiting in adults
D 2 receptors are found both post- and pre Which drugs block receptor sites for dopamine? Dopamine Antagonists Dopamine antagonists are a class of drugs that bind to and block dopamine receptors
Trimethobenzamide and ondansetron offer antiemetic effects that are achieved without inhibition of dopamine receptors, and they can be considered for use in PD
Block H 1 receptors
Complications may include rhabdomyolysis, high blood potassium, kidney failure, or
The TMN neurons express orexin-2 receptors
All antipsychotics block dopamine D 2 receptors, but some dissociate from the receptors more quickly than others
How Does Promethazine Work? Promethazine blocks the histamine your body makes during allergic reactions