Famotidine covid mechanism of action

May 16, 2022 · Here we hypothesized that famotidine activates the inflammatory reflex, a brain-integrated vagus nerve mechanism which inhibits inflammation via alpha 7 nicotinic acetylcholine receptor (α7nAChR) signal transduction, to prevent cytokine storm. Famotidine primarily works by blocking the effects of histamine and has some potential mechanisms of action that may contribute to its anti-inflammatory properties, including the inhibition of the production of certain Mar 23, 2021 · We propose that the principal mechanism of action of famotidine for relieving COVID-19 symptoms involves on-target histamine receptor H 2 activity, and that development of clinical COVID-19 involves dysfunctional mast cell activation and histamine release

2024-03-19
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  1. The definite viricidal effect of famotidine is not established
  2. These cells trigger other molecular pathways by secreting histamines