11 Photosensitivity and Skin Discoloration
Blood tests may be needed to check for unwanted effects
Amiodarone inhibits sodium (Na), slightly prolonging phase 0 of the action potential
Conclusions
Amiodarone (Cordarone, Nextrone, Pacerone) has been documented to cause ocular toxicity
corneal degeneration, photosensitivity, lens opacities, macular degeneration, photosensitivity Other symptoms causing discontinuations less often included visual disturbances, photosensitivity, blue skin discoloration, hyperthyroidism, and hypothyroidism
, amiodarone [51, 52], azathioprine [53, 54], vemurafenib [55, 56] and voriconazole [57, 58]
doi: 10
89 Photosensitivity may even occur months after the withdrawal of amiodarone due to its
Maintenance dose (100 to 400 mg daily) varies depending on multiple factors, including heart rate
The rate increases at higher doses of amiodarone, particularly long-term use of doses over 500 mg daily
FERGUSON and others, A study of cutaneous photosensitivity induced by amiodarone, British Journal of Dermatology, Volume 113, Issue 5, 1 November 1985, Pages 537–549, Mechanism of Amiodarone Phototoxicity
Risk of doxycycline-induced phototoxicity is influenced by multiple factors including treatment dose, UV wavelength, skin photo-type and geographical location of the patient
It is not known whether the lung problems caused by amiodarone are due to direct damage by the drug to the lung tissues, an immune reaction to the drug, or to some other mechanism
Mechanism of Action of Amiodarone It is a long acting class-3 antiarrhythmic drug
Heart failure 6