The serotoninergic antidepressants are the first-line treatment of choice for severe PMDD
Suggested doses are fluoxetine 20 mg a day, sertraline 50 mg to 100 mg a day, citalopram 20 mg a day, escitalopram 20 mg a day, or paroxetine 20 mg a day
See also Warning section
The maximum recommended dose of fluoxetine is 80 mg
) Prozac belongs to a group of drugs called The relatively rapid symptom improvement after initiation of serotonin reuptake inhibitors (SRIs) in severe premenstrual syndrome and premenstrual dysphoric disorder (PMDD;
Most patients without worsening symptoms can receive outpatient treatment, especially with family support
A patient prescribed a dose of fluoxetine that is less than 20 mg or a dose
Fluoxetine is also used to reduce or eliminate the symptoms of obsessive-compulsive disorder (OCD) as well as to treat the eating disorder bulimia nervosa
painful, red lumps under the skin, mostly on the legs
How to take it Adults—At first, 20 milligrams (mg) of fluoxetine and 5 mg of olanzapine once a day, taken in the evening
In a study comparing continuous dosing of fluoxetine 20 and 60 mg/day to placebo, both doses were proven to be effective, but there was no statistically significant added benefit for the 60–mg/day compared with the 20–mg/day dose
The average norfluoxetine steady-state concentrations in these children were 1
The oral bioavailability of fluoxetine is 90% as a result of hepatic first pass metabolism
11 Fluoxetine is very lipophilic and highly plasma
Twelve women with PMDD received fluoxetine (20 mg daily) during the luteal phase of the menstrual cycle
Dosages >18 mg of olanzapine and 75 mg of fluoxetine not evaluated in clinical studies
to max 100 mg qd if inadequate response after 12wk: combo may incr
You can find detailed information about this drug in the official Patient Information Leaflet (PIL)
Dosage and Administration
This helps to prevent any withdrawal symptoms
For people being treated for bulimia, the usual daily dose is 60 mg (three capsules or 15 ml liquid medicine)
Initially, SSRIs were prescribed for PMS every day of the month; however, recent studies indicate that intermittent dosing during the luteal phase may also be effective and may minimize the risk of side effects