Nishio et al investigated the interaction between amlodipine and simvastatin in patients with hypercholesterolemia and hypertension
7 +/- 4
A model for drug interaction between amlodipine and simvastatin was developed using concentration data obtained from a multiple-dose study consisting of
The study explored primarily the pharmacokinetic interaction between simvastatin and anacetrapib, as it relates to the effect of anacetrapib on simvastatin
Sixty percent of the usual dose was the optimal simvastatin dose that can minimize the interaction with amlodipine 10 mg
In conclusion, this study has quantitatively described the pharmacokinetic interaction between simvastatin and amlodipine using a modeling
The patients were given, for
Pharmacokinetic studies have shown that the bioavailability of simvastatin increases in patients, who received Rosuvastatin, a hydroxy methylglutaryl coenzyme A reductase inhibitor; telmisartan, an angiotensin receptor blocker; and amlodipine, a calcium channel inhibitor, are commonly prescribed together for the treatment of hypertension nonresponsive to monotherapy and accompanied by dyslipidemia
05), similar to that caused by the amlodipine pretreatment
Combining these medications may significantly increase the blood levels of simvastatin
Received December 7, 2009; accepted February 24, 2010 Correspondence to H
Neither the number of prescriptions nor the analysis of the diagnoses showed an increased risk of muscular discomfort in relation with a combined prescription of amlodipine and simvastatin
Methods The PBPK model of each drug was developed using Simcyp software (Version 15
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Coadministration of simvastatin with amlodipine increases the systemic exposure of simvastatin