Pharmacokinetic interaction between amlodipine and simvastatin

Seventeen patients randomly received daily doses of 20 mg simvastatin and 5 mg amlodipine for 6 weeks, either with both drugs at 7:00 PM (concurrent) or with simvastatin at 7:00 PM followed by amlodipine at 11:00 PM (non-concurrent). Eight patients with hypercholesterolemia and hypertension were enrolled

2024-03-28
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  1. Age and weight had significant effects on amlodipine concentrations
  2. 6 +/- 3
  3. Amlodipine
  4. Pharmacokinetic Interactions