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ST-91, a polar structural analog of clonidine that does not cross the blood -brain barrier, did not reproduce the effects of clonidine when administered at an equivalent dose
75%) for knee arthroscopic
4205-90-7
1980
Gabapentin, a structural analog of neurotransmitter gamma amino butyric acid acts by inhibiting calcium influx and subsequent release of excitatory neurotransmitter in pain pathways by binding to α 2 subunit of the presynaptic voltage-gated Ca 2 + channels
Xylazine is a non-narcotic compound utilized for sedation, pain relief, and muscle relaxation in veterinary medicine, where it is often referred to as "anestesia de caballo" or "horse anesthetic
Fentanyl and its analogs have been mainstays for the treatment of severe to moderate pain for many years
Diphenoxylate (5
5) is a novel, potent, and selective inhibitor of calmodulin that plays an important role in the regulation of wide variety of Clonidine, guanabenz and guanfacine are structurally related compounds and have similar antihypertensive profiles
LSD remains a popular recreational drug but is also becoming an important research tool for medical and neuroscience studies
1 Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, 117997 Russia
Clonidine / analogs & derivatives agents are structural analogs of clonidine; however, while mox-onidine combines an imidazoline ring with a second heterocyclic ring structure, rilmenidine consists of an oxazoline moiety, substi-tuting an oxygen for one of the nitrogens in the imidazoline ring (Figure 1)
The most well known compound from this family, methylphenidate, is widely prescribed around the world for the treatment of attention deficit hyperactivity disorder (ADHD) and certain other indications
A survey of novel small-molecule therapeutics reveals that the majority of them result from analogue design and that their market value represents two-thirds of all small-molecule sales
The same is true for medicinal chemists looking for Electronic structure of clonidine and some related 2-(phenylimino)imidazolidines with CY-adrenergic activity, J
Pharmacol
Clonidine