Asthma is a common medical condition that impacts 3 to 8 percent of all pregnancies [ 1-3 ]
theophylline; Many doctors agree that the safest option is for pregnant women with asthma to take medications and avoid flare-ups, which can lead to
Anticholinergics: While these drugs appear safe during pregnancy, little research has been done
Safe During Breastfeeding: Theophylline passes from the mother to infant in breast milk
Pregnancy - 1st trimester Theophylline is safe and effective for the approved indications in pediatric patients
[1,2] Maternal theophylline use may occasionally cause stimulation and irritability and fretful sleep in
In a randomized controlled trial, there were no differences in asthma exacerbations or maternal or perinatal outcomes in the theophylline versus the beclomethasone dipropionate treatment groups
Theophylline was first identified as having potential for asthma as a bronchodilator in 1921 and 1922 [ 1 ], but general use as a bronchodilator was not seen until the 1930s
This action appears to be due to enhancement of calcium uptake Based on a review of the available information, it is recommended that mild asthma during pregnancy be managed with inhaled beta 2-agonists, as required; step therapy for moderate asthma would include inhaled sodium cromoglycate (cromolyn sodium), inhaled beclomethasone dipropionate and oral theophylline
To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of Use is generally safe when used at the recommended doses (serum concentrations 5 to 12 mcg/mL) however maternal adverse events may be increased and efficacy may be decreased in pregnant women
1% +/- 4
It was originally used as a bronchodilator but the relatively high doses required are associated with frequent side effects, so its use declined as inhaled β 2-agonists became more widely used
Pregnancy
This article reviews the management of asthma during pregnancy and the safety of asthma medications
In addition, it stresses the role of health care providers in meticulously monitoring the drug concentrations to avoid
These effects ceased with discontinuation and recurred on rechallenge over the next 9 months
The infant was placed on Theophylline (Alcophyllex) when the If safety and efficacy can be effectively monitored, no change in formulation or administration is required after bariatric surgery; however, if swallowing is an issue after surgery, capsule formulations may be opened and sprinkled on soft foods
They include beta 2-agonoists, corticosteroids, cromolyn, leukotriene modifiers, theophylline, and
[1,2] Maternal theophylline use may occasionally cause stimulation and irritability and fretful sleep in infants
Safety Guidelines Include early sampling times of 1, 2, and 4 hours and continue every 2 hours until at least 80% of the drug is released to provide assurance against premature release of drug (dose dumping) from the formulation