11 However, the main benefit of a tocolytic drug is the prolongation of pregnancy for a 48-hour period to allow the steroid effect to enhance fetal lung maturity
In this setting, antihypertensive agents are mainly used to prevent and treat severe hypertension; to prolong pregnancy for as long as safely possible, thereby maximizing
Patients in the active-treatment group were prescribed a first-line antihypertensive drug for pregnancy (labetalol or extended-release nifedipine, supplied by trial investigators) or other Standard initial dosing of extended-release nifedipine in pregnancy is 30 mg daily
The evidence from overseas for the safe use of nifedipine in early pregnancy is accumulating; therefore, its use in Japan before 20 weeks of gestation
Figure 1 Open in figure viewer PowerPoint Nifedipine binds and blocks L-type calcium channels in smooth muscle predominantly in the coronary and peripheral vasculature, resulting in vasodilation
Preterm labor (PTL) is a common and serious pregnancy disorder that can cause long-term neurological issues in the infant