Amiodarone inhibits P-glycoprotein which may theoretically result in increased intrace- llular colchicine concentrations and decreased hepatic and renal excretion of the drug
Antiarrhythmic Drugs Amiodarone3-5 Dofetilide (Tikosyn)3-5 Disopyramide (Norpace)3-5 Dronedarone (Multaq)3-5 Anti-Inflammatory Drugs Colchicine (Colcrys)3-4 Increased concentration of colchicine may result in Drug-Drug Interactions Between Ritonavir-Boosted Nirmatrelvir (Paxlovid) and
1,2 The botanical alkaloid compound is derived from the flower Colchicum autumnale, a medicinal plant described as early as 1550 BC in the Egyptian Ebers Papyrus used to treat pain and swelling
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Three proteins play pivotal roles in colchicine pharmacokinetics: the colchicine receptor, tubulin, which governs the plasma elimination half-life of the drug; intestinal and hepatic CYP3A4, which Applies to: amiodarone and Lipitor (atorvastatin) Amiodarone may increase the blood levels of atorvastatin
Sparfloxacin
If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of
This product is available in the following dosage forms: Tablet
The interaction between colchicine and statins is further complicated by the fact that both classes of drugs, independently, are recognized occasionally to cause muscle toxicity
5 mg daily) is effective for preventing gout flare and cardiovascular (CV) events in a wide range of patients
Applies to: amiodarone and tramadol
Considering this, colchicine toxicity may be augmented with the use of amiodarone or dronedarone, and vice-versa
For example, taking a cough medicine ( antitussive) and a drug to help you sleep (sedative drug-drug interaction (DDI) is a pharmacokinetic or pharmacological influence Amiodarone Lovastatin Increased statin exposure/increased risk for muscle-related toxicity Colchicine Atorvastatin Increased statin or colchicine exposure/ increased risk for muscle-related toxicity Variable Combination may be considered Concomitant use of several drugs with colchicine may potentiate the development of myopathy
If coadministration is necessary, use caution if using high-dose fluconazole (800 mg)
Seven separate drug-drug interaction (DDI) studies were performed to elucidate the in vivo effects of concomitant treatment with colchicine and known inhibitors of cytochrome P450 3A4 (CYP3A4)/P-glycoprotein
Recent Findings Recent evidence about therapeutic targets on pericarditis has demonstrated that NALP3 inflammasome blockade is the
In principle, the risk of interactions considering the profile of the drug and Paxlovid is probably very low
Combining these drugs can increase the risk of an irregular heart rhythm that may be serious