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Explore in 3D: Structure | Sequence Annotations | Electron Density | Validation Report | Ligand Interaction 3V4I, 3V6D, 3V81
Nevirapine is a potent inhibitor of HIV replication and is a major component of
Endonucleases cleave the RNA strand of RNA/DNA hybrids and are widely found in both prokaryotes and eukaryotes, as well as in retroviruses [19,28,36,37]
Five NNRTIs (nevirapine, delavirdine, efavirenz, etravirine and rilpivirine) have been approved by US Food and Drug Administration (FDA) for clinical use
5 A, allowing the determination of water structure within the NNRTI-binding pocket, essential for an understanding of nevirapine binding
Download Structure of HIV-1 reverse transcriptase in complex with RNA-DNA and Nevirapine (red), animated 3D cartoon and Gaussian surface models, chain id color scheme, based on PDB 4puo, black background Stock Video and
, 1994), and maraviroc (Wood The nevirapine-ternary structure presented in this study defines the impact of nevirapine binding on DNA positioning and RT–DNA interactions
The immediate-release tablet and liquid forms of nevirapine
Upon viral entry, HIV-1 reverse transcriptase (RT) initiates from a host tRNA Lys 3 primer bound to the vRNA genome and is the target of key antivirals, such as