“Dutasteride is a medication that blocks an enzyme known as 5-alpha reductase (5-AR),” explains Dr
However, finasteride only inhibits part of the conversion, whereas dutasteride
This multicenter phase II study evaluated the therapeutic efficacy and safety of abiraterone with prednisolone plus dutasteride and demonstrated favorable efficacy, represented by 85
This enzyme changes testosterone to another hormone that causes the prostate to grow
The 5-alpha-reductase enzyme exists in two forms: type 1 and type 2
Obat ini bisa membantu mengatasi keluhan sulit buang air kecil, aliran kencing yang lambat, rasa tidak tuntas setelah buang air kecil, dan rasa ingin buang kecil yang bolak-balik muncul
Sir, Dutasteride is used off-label worldwide in the treatment of androgenetic alopecia (AGA) and has proved its efficacy in different studies
BPH is a noncancerous enlargement of the prostate gland that usually happens to men after the age of 50
The differences are highly Pharmacology
However, finasteride only inhibits part of the conversion, whereas dutasteride completely blocks conversion
The primary end point was a 50% prostate-specific antigen response rate
Researchers have pursued synthesis of nonsteroidals to inhibit 5α-reductase due to the undesired side effects of steroidals
However, phase II study results indicated that oral dutasteride at both 0
Abstract Dutasteride (Avodart®), an oral synthetic 4-azasteroid, is a potent, selective, irreversible inhibitor of type 1 and type 2 5α-reductase (5AR), the enzyme that converts testosterone to dihydrotestosterone (DHT) intracellularly
Common side effects
Tamsulosin is an alpha blocker (specifically an alpha 1a-adrenoreceptor antagonist Dutasteride is associated with a low rate of transient serum aminotransferase elevations, but has yet to be linked to instances of clinically apparent acute liver injury
However, dutasteride inhibits all three isoforms of 5α-reductase (types I, II, and III), achieving a reduction in circulating DHT levels of up to 98%, while finasteride only inhibits type II and III, resulting in a 65-70% reduction in DHT
5-mg dutasteride was superior to 5-mg finasteride in improving scalp hair growth in men between ages 21 and 45 years with MPHL as judged by target area hair counts, expert panel assessment, and investigator assessment at 12 and 24 weeks