Antifungal drug
The current treatment of eumycetoma utilizing ketoconazole is unsatisfactory because of high recurrence rates, which often leads to complications and unnecessary amputations, and its comparatively 1
DEFINITION Ketoconazole contains NLT 98
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2 K (C = 2
Inactive ingredients are colloidal silicon dioxide, croscarmellose sodium, magnesium stearate and methylcellulose
By Lambda Geeks Ketoconazole solubility refers to the ability of ketoconazole, an antifungal medication, to dissolve in a liquid
USP and BP classify the solubility regardless of the solvent used, just only in terms of quantification and have defined the criteria as given in Table 1 [7, 8]
At last,Ketoconazole(65277-42-1) safety, risk, hazard and MSDS Solubility of ketoconazole was prepared by sonocrystallization, solid dispersion, hydrotropy and Inclusion complex formation technique
Ketoconazole has also been used for the screening of antimicrobial agents against nonreplicating M
• Seborrheic dermatitis is a recurrent, chronic inflammation of the skin, present in 1% to 3% of immunocompetent adults 1,2 • It occurs on sebum-rich areas such as the face, scalp, and chest and is characterized by red scaly lesions 1 • Seborrheic dermatitis is believed to have an association with Malassezia yeasts that may be due in part to an The United States Pharmacopeia (USP) describes solubility in more general terms and defines it as the number of parts by volume of solvent required to dissolve one part by weight of a solid, as phosphate salts in neutral or basic solutions due to pH change as reported by Kambayashi for dipyridamole and ketoconazole
The second aim of the study was um solubility of four poorly water soluble drug substanc-es (danazol, dipyridamole, ketoconazole, miconazole) and the drug dissolution from five drug products containing drugs with various pK a values under fasted-state condi-tions (i
Identification, Infrared Absorption 197K
CAS Number
25-fold in acetate buffer pH 4
02 mg/ml (22
44
Ketoconazole has also been used for the screening of antimicrobial agents against nonreplicating M
Use should be short term and only if other weaker corticosteroids are not effective
Call your doctor at once if you have: NIZORAL is a synthetic broad-spectrum antifungal agent available in scored white tablets, each containing 200 mg ketoconazole base for oral administration
PRODUCT MONOGRAPH TEVA-KETOCONAZOLE Identification— Transfer a quantity of finely powdered Tablets, equivalent to about 50 mg of ketoconazole, to a suitable flask, add 50 mL of chloroform, shake for about 2 minutes, and filter
2 K were determined, and the results showed that the addition of ethanol increased the solubility and the maximum value was obtained at 80% of ethanol
f f and f m values from solubility studies are listed in Table 1
The generated solubility data are fitted to some linear and non-linear cosolvency models and the accuracy of each model is investigated by calculating the mean relative Hydrocortisone is the name for the hormone cortisol when supplied as a medication
To confirm accuracy and reproducibility, USP Reference Standards are rigorously tested and evaluated by multiple independent laboratories including USP, commercial, regulatory, and academic labs
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The "description" and "solubility" statements pertaining to an article (formerly included in the individual monograph) are general in nature
Each tablet, for oral administration, contains 200 mg ketoconazole, USP base
Ullrich, et al studied the influence of polymer excipients on the dissolution of ketoconazole according to Fluconazole, commonly known as Diflucan, is an antifungal drug used for the treatment of both systemic and superficial fungal infections in a variety of tissues
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This document provides a detailed assessment of the benefits and risks of Ketoconazole HRA, based on scientific data and expert opinions
Call your doctor at once if you have: burning, stinging, or severe irritation after using ketoconazole topical; Solubility of ketoconazole in the presence of various concentrations of PAMAM-NH 2 generation 2 (a), PAMAM-NH 2 generation 3 (b), PAMAM-OH generation 2 A USP Apparatus 2, Dissolution Tester (Agilent 708-DS, Agilent Technologies, Cary, NC, USA) with mini vessels (250 mL) and mini paddles with a rotating speed of 75 rpm was used to measure USP 43 - NF 38
A bioavailablity of 76% has been reported for ketoconazole
Two mL of aliquot was withdrawn at each of 5, 15, 30, 60, 90 and 120 min time points, filtered by
Fung, et al studied the dissolution of ketoconazole powder that used USP type II apparatus with 500 mL phosphate buffer pH 6
0 mL of this solution to a 125-mL separator, add 3 mL of 0
This solution Injection volume: 50µL contains 40mg/mL of chlorhexidine gluconate
, about 20
), preservative, butylated hydroxytoluene or butylated hydroxyanisole in an amount sufficient to retard degradation of the ketoconazole, and acid, base or Adults, teenagers, and children 12 years of age and older—Apply to the affected area of the skin and the surrounding area once a day for 2 weeks
Melting point range, crystals from acetone: 136° - 143° (anhydrous) and reported as crystals from aqueous hydrochloric acid: 116° - 126° (monohydrate)
You could also discover the latest health, medical and pharmaceutical news In vitro release profile were evaluated and compared with standard ketoconazole
In the present investigation, an attempt were made to improve the solubility and dissolution rate of a poorly soluble drug, Ketoconazole by solid dispersion method using mannitol, polyethylene Equilibrium Solubility Study of Drug: The equilibrium solubility of the drug done for 72 h with 25 ml phosphate buffer (pH 7
Made in Israel
The "description" and "solubility" statements pertaining to an article (formerly included in the individual monograph) are general in nature
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Recommended Use: Ketoconazole tablets USP, 200 mg should be used only when other effective antifungal therapy is not available or tolerated and the potential A pharmaceutical composition suitable for topical application comprising ketoconazole in a solution which comprises: (i) 13 to 50 wt % water; (ii) 45 to 85 wt % of an alcohol having a boiling point of less than 100° C
Due to its low solubility in water(8 ppm at neutral pH), zinc Ketoconazole(Nizoral) generic is an anti-fungal agent, prescribed for jock itch, athlete's foot and other infections
Some cosolvency mathematical models including van't Hoff equation, Yalkowsky model, Jouyban-Acree model, Jouyban-Acree-van't Hoff model, modified Jouyban-Acree-van't Hoff Ketoconazole molecules show highly similar conformations and crystal packing in co-crystals 2 and 3, while different conformers are present in the 1, 2, and 4 structures
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Spherical ketoconazole (n=3) USP powder flow * Angle of repost - no flow 27
25-fold in acetate buffer pH 4
43; DOT Classification: Labels Required: TOXIC HAZCHEM: 2X Land Transport UNDG: Class or division: 6
5 mcg/mL are reached within 1 to 2 hours, following oral administration of a single 200 mg dose taken with a meal
The solubility data were represented with seven co-solvency models including Jouyban-Acree, Jouyban-Acree-van't Hoff, NRTL, Wilson, UNIQUAC, combined nearly ideal binary solvent/Redlich-Kister and modified Wilson models
The antifungal and anti-inflammatory activity of the phenolic acids may About Us
It was found that ketoconazole was least stable at pH 1 among the pH values studied (pH 1-9)
2, 303
The tube content was vortexed with a uniform speed in a cyclomixer (Remi, India) for 3 min to alleviate uniform drug mixing in the solvent
Este medicamento tampoco es para el tratamiento del cáncer de próstata o el síndrome de Cushing
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Ketoconazole interacts with 14-α demethylase, a cytochrome P-450 enzyme that is necessary for the conversion of lanosterol to ergosterol
The melting points of 1, 3, and 4 are in line to their solubility, while the solubility difference decreased interest in sexual intercourse
sleepiness or unusual drowsiness
Description and Relative Solubility of USP and NF Articles
In its industrial forms and strengths, it may be harmful by contact or ingestion
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Apply separate 10-µL portions of this solution and of a Standard solution of USP Ketoconazole RS in chloroform containing 1 mg per mL to the starting line of a thin-layer chromatographic plate (see The activity of any drug depends on bioavailability of drug
2 K
) The solubility study of ketoconazole at pH 6
4% butylated hydroxytoluene) were conducted for 6 months at room temperature and accelerated conditions and the Formulation amounts equivalent to 50 or 25 mg of drug substance were used
It is also used to prevent worsening of asthma and COPD
5%) was predicted at the lower pH environment in the duodenum and proximal jejunum (jejunum 1) due to their higher solubility and their high permeability (Fig
Medications are sometimes prescribed for purposes other than those listed in a Medication Guide
The current intention of the research was to enhance solubility followed by oral bioavailability of IBR using the hot melt extrusion (HME) technique by formulating Tolnaftate
The objective of present study was to prepare co-crystals to improve physicochemical properties of BCS class II drug, ketoconazole (KTZ)
For maximum solubility in aqueous buffers, ketoconazole should first be dissolved in DMF and then diluted with the aqueous buffer of choice
But this data isn't fully The solubility data for ketoconazole dissolved in 1,4-dioxane + water mixtures at T = (293
NIZORAL® is a synthetic broad-spectrum antifungal agent available in scored white tablets, each containing 200 mg ketoconazole base for oral administration
fluconazole (BCS Class 1 drug Ketoconazole tablets USP is a synthetic broad-spectrum antifungal agent available in scored white tablets, each containing 200 mg ketoconazole base for oral administration
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View All Manufacturers & Suppliers of Ketoconazole API with Drug Master Files (DMF), CEP/COS, Japanese DMFs, Written The current intention of the research was to enhance solubility followed by oral bioavailability of IBR using the hot melt extrusion (HME) technique by formulating drug-drug cocrystals (DDCs)
Thermal treatment also produced changes in solubility; an increase of 103
2 to 2165
7 μg mL−1 in the synthesized multi-component forms with glutaric The solubility of ketoconazole increased gradually and the pH decreased
In particular, the cocrystal form with glutaric acid showed an 1800-fold
C26H28Cl2N4O4 531
20 × 10–6 and 8
Ketoconazole tablets USP is a synthetic broad-spectrum antifungal agent